Seamers Anrich Nortje and Kagiso Rabada return to the 50-over setup after being rested for the recent ODI series against the West Indies.
The first match will take place at Willowmoore Park in Benoni on Friday, with the second at the Wanderers in Johannesburg on Sunday.
Temba Bavuma’s team must win both to stand a chance of qualifying directly for the 2023 World Cup in India.
“We have named our strongest possible squad for these games given the importance of these matches in the context of qualifying for the World Cup,” said Proteas coach Rob Walter. “We have a job to do and I am confident that with this group of players, we can get the job done.”
Proteas ODI squad: Temba Bavuma (c, Lions), Quinton de Kock (Titans), Bjorn Fortuin (Lions), Reeza Hendricks (Lions), Marco Jansen (Warriors), Heinrich Klaasen (Titans), Sisanda Magala (Lions), Aiden Markram (Titans), David Miller (Dolphins), Lungi Ngidi (Titans), Anrich Nortje (Warriors), Wayne Parnell (Western Province), Kagiso Rabada (Lions), Tabraiz Shamsi (Titans), Rassie van der Dussen (Lions).
