The Proteas batsman fractured his left index finger while fielding on the opening day of the second Test at Old Trafford and will return to South Africa.
Lions all-rounder Wiaan Mulder has been added to the squad.
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PROTEAS
Proteas
Injured Rassie to miss third Test
Rassie van der Dussen has been ruled out of the Test series against England at The Oval.
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